Investigating the role of reduced BDNF in depression and aging.

Overview:

We have provided evidence of reduced BDNF signaling in postmortem brain of depressed subjects and of aged controls, and confirmed that low BDNF contributes to the molecular and behavioural changes associated with these conditions using mouse genetic models. Current efforts are aimed at characterizing underlying mechanisms and developing small molecules that target these deficits.

Publications:

– Oh H, Lewis DA, Sibille E. The Role of BDNF in Age-Dependent Changes of Excitatory and Inhibitory Synaptic Markers in the Human Prefrontal Cortex. Neuropsychopharmacology. 2016 Dec;41(13):3080-3091. PubMed PMID: 27417517; PubMed Central PMCID: PMC5101556.

– McKinney BC, Lin CW, Oh H, Tseng GC, Lewis DA, Sibille E. Hypermethylation of BDNF and SST Genes in the Orbital Frontal Cortex of Older Individuals: A Putative Mechanism for Declining Gene Expression with Age. Neuropsychopharmacology. 2015 Oct;40(11):2604-13. PubMed PMID: 25881116; PubMed Central PMCID: PMC4569950.

– Tripp A, Oh H, Guilloux JP, Martinowich K, Lewis DA, Sibille E. Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder. Am J Psychiatry. 2012 Nov;169(11):1194-202. PubMed PMID: 23128924; PubMed Central PMCID: PMC3638149.

– Guilloux JP, Douillard-Guilloux G, Kota R, Wang X, Gardier AM, Martinowich K, Tseng GC, Lewis DA, Sibille E. Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression. Mol Psychiatry. 2012 Nov;17(11):1130-42. PubMed PMID: 21912391; PubMed Central PMCID: PMC3237836.