Investigating the role of SST-positive GABA neurons in mood and cognition.

Overview:

We have reported cellular and molecular changes affecting this specific subtype of GABA neurons. Using mouse genetic models and pharmacology, we have shown that deficits in this cell type induce cognitive and mood deficits and that targeting these deficiencies has pro-cognitive, anxiolytic and antidepressant potential. Current efforts are aimed at developing small molecules that target these deficits.

 

Publications:

– Fee C, Banasr M, Sibille E. Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives. Biol Psychiatry. 2017 Oct 15;82(8):549-559. PubMed PMID: 28697889; PubMed Central PMCID: PMC5610074.

– Sibille E. Reduced Somatostatin Expression or Somatostatin-Positive Gamma-Aminobutyric Acid Neurons: A Shared Pathology Across Brain Disorders. Biol Psychiatry. 2017 Mar 15;81(6):467-469. PubMed PMID: 28190426.

– Lin LC, Sibille E. Somatostatin, neuronal vulnerability and behavioral emotionality. Mol Psychiatry. 2015 Mar;20(3):377-87. PubMed PMID: 25600109; PubMed Central PMCID: PMC4355106.

– Northoff G, Sibille E. Why are cortical GABA neurons relevant to internal focus in depression? A cross-level model linking cellular, biochemical and neural network findings. Mol Psychiatry. 2014 Sep;19(9):966-977. PubMed PMID: 25048001; PubMed Central PMCID: PMC4169738.