Methods development

Overview:

In support of the research effort described above, we have been consistently involved in methods development. Examples include novel methods in biostatistics, bioinformatics, gene network and graph theory analyses and integrated behavioural scoring.

 

Publications:

– Guilloux JP, Seney M, Edgar N, Sibille E. Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: relevance to emotionality and sex. J Neurosci Methods. 2011 Apr 15;197(1):21-31. PMID: 21277897. PMCID: PMC3086134.

– Kang DD, Sibille E, Kaminski N, Tseng GC. MetaQC: objective quality control and inclusion/exclusion criteria for genomic meta-analysis. Nucleic Acids Res. 2012 Jan;40(2):e15. PMID: 22116060. PMCID: PMC3258120.

– Chang LC, Jamain S, Lin CW, Rujescu D, Tseng GC, et al. A conserved BDNF, glutamate- and GABA-enriched gene module related to human depression identified by coexpression meta-analysis and DNA variant genome-wide association studies. PLoS One. 2014;9(3):e90980. PMID: 24608543. PMCID: PMC3946570.

– Gaiteri C, Ding Y, French B, Tseng GC, Sibille E. Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders. Genes Brain Behav. 2014 Jan;13(1):13-24. PMID: 24320616. PMCID: PMC3896950.