Publications

2018

Prevot TD#, Li G, Vidojevic A, Santrac A, Misquitta K, Fee C, Knutson DE, Arnold LA, Scholze A, Fisher JL, Banasr M, Cook JM, Savic M,  Sibille E (2018)Pro-cognitive, anxiolytic and antidepressant properties of novel GABAA receptor positive modulators with preferential efficacy at the α5-subunit, (submitted)

Shukla R#, Prevot TD, French L, Isserlin R, Rocco BR, Banasr M, Bader GD, Sibille E*.The relative contributions of cell dependent cortical microcircuit aging to cognition and anxiety. (submitted)

Oh H#, Piantadosi SC, Rocco BR, Lewis DA, Watkins SC, Sibille E*.The role of dendritic BDNF transcripts on altered inhibitory circuitry in depression. (submitted)

McKinney BC#, Lin C, Oh H, Lewis DA, Tseng G, Sibille E*.Age-Associated DNA methylation and Gene Expression in the Human Orbital Frontal Cortex Reveal a Putative Mechanism for Age-by-Disease Interactions (submitted)

Sumitomo A, Yukitake H, Hirai K, Horike K, Ueta K, Chung Y, Warabi E, Yanagawa T, Kitaoka S, Furuyashiki T, Narumiya S, Hirano T, Niwa M, Sibille E, Hikida T, Sakurai T, Ishizuka K, Sawa A, Tomoda T. Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons. Hum Mol Genet. DOI: 10.1093/hmg/ddy219.
PMID: 29893844

Caravaggio F, Scifo E, Sibille E, Hernandez-Da Mota SE, Gerretsen P, Remington G, Graff-Guerrero A. Expression of dopamine D2 and D3 receptors in the human retina revealed by positron emission tomography and targeted mass spectrometry. Eye Res. 2018 Jun 5;175:32-41. doi: 10.1016/j.exer.2018.06.006
PMID: 29883636

Lissemore JI, Bhandari A, Mulsant BH, Lenze EJ, Reynolds III CF, Karp JF, Rajji TK, Noda Y, Zomorrodi R, Sibille E, Daskalakis ZJ, Blumberger DM. Reduced GABAergic Cortical Inhibition in Aging and Depression. Neuropsychopharmacology. Neuropsychopharmacology. 2018 May 17. doi: 10.1038/s41386-018-0093-x.
PMID: 29849055

Seney M.L, Huo Z, Cahill K., French L., Puralewski R., Zhang J., Logan R.W, Tseng G., Lewis D.A, Sibille E. Opposite molecular signatures of depression in men and women. Biol Psychiatry. 2018 Feb 19. pii: S0006-3223(18)30065-9. doi: 10.1016/j.biopsych.2018.01.017
PMID: 29548746

Li G, Stephen M.R, Kodali R, Zahn N.M, Poe M.M, Tiruveedhula P.B, Huber A.T, Schussaman M.K, Qualmann K, Panhans C.M, Raddatz N.J, Baker D.A, Prevot T.D, Banasr M, Sibille E*, Arnold L.A, Cook J.M. Synthesis of chiral GABAA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression. Archive for Organic Chemistry. Arkivoc 2018, part iv, 0-0

Nikolova Y#, Misquitta K#, Rocco B, Prevot T, Knodt A, Ellegood J, Voineskos A, Lerch J, Hariri A, Sibille E*, Banasr E. Shifting Priorities: Highly conserved behavioral and brain network adaptations to chronic stress across species. Translational Psychiatry. 2018 Jan 22;8(1):26. doi: 10.1038/s41398-017-0083-5.
PMID: 29353879

Gunduz-Cinar O, Brockway E, Lederle L, Wilcox T, Halladay L, Ding Y, Oh H, Busch E, Kaugars K, Flynn S, Limoges A, Bukalo O, MacPherson K, Masneuf S, Pinard C, Sibille E, Chesler E, Holmes A. Identification of a novel gene regulating amygdala-mediated fear extinction. Mol Psychiatry. 2018 Jan 8. doi: 10.1038/s41380-017-0003-3.
PMID: 29311651

2017

Mancarci BO, Toker L, Tripathy SJ, Li B, Rocco B, Sibille E, Pavlidis P. Cross-Laboratory Analysis of Brain Cell Type Transcriptomes with Applications to Interpretation of Bulk Tissue Data. eNeuro. 2017 Nov 30;4(6). pii: ENEURO.0212-17.2017. doi: 10.1523/ENEURO.0212-17.2017. eCollection 2017 Nov-Dec. PMID: 29204516

Rocco BR, Oh H, Shukla R, Mechawar N, Sibille E. Fluorescence-based cell-specific detection for laser-capture microdissection in human brain.Sci Rep. 2017 Oct 27;7(1):14213. doi: 10.1038/s41598-017-14484-9
PMID: 29079825 

Scifo E, Pabba M, Kapadia F, Ma T, Lewis DA, Tseng GC, Sibille E. Sustained Molecular Pathology Across Episodes and Remission in Major Depressive Disorder. Biol Psychiatry. 2017 Aug 18. doi: 10.1016/j.biopsych.2017.08.008
PMID: 28935211.

Banasr M, Lepack A, Fee C, Duric V, Maldonado-Aviles J, DiLeone R, Sibille E, Duman RS, Sanacora G. Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression. Chronic Stress. 2017 Feb 1. doi: 10.1177/2470547017720459
PMID: 28835932 .

Pabba M, Scifo E, Kapadia F, Nikolova YS, Ma T, Mechawar N, Tseng GC, Sibille E.
Resilient protein co-expression network in cortical layer 2/3 during human aging.
Neurobiology of Aging. 2017 Jul 5. doi: 10.1016/j.neurobiolaging.2017.06.023.
PMID: 28750307.

French L, Ma T, Oh H, Tseng GC, Sibille E. Age-related gene expression in the frontal cortex suggests synaptic function changes in specific inhibitory subtypes. Front Aging Neuroscience. 2017 May 29. doi: 10.3389/fnagi.2017.00162
PMID: 28611654.

Fee C, Banasr M, Sibille E. Somatostatin-positive GABA Neuron Deficits in Depression: Cortical Microcircuit and Dimensional Perspectives. Biol Psychiatry 2017 doi: 10.1016/j.biopsych.2017.05.024 Biological Psychiatry.
PMID: 28697889.

DeMichele-Sweet MAA, Weamer EA, Klei L, Vrana DT, Hollingshead DJ, Seltman HJ, Sims R, Foroud T, Hernandez I, Moreno-Grau S, Tárraga L, Boada M, Ruiz A, Williams J, Mayeux R, Lopez OL, Sibille EL, Kamboh MI, Devlin B, Sweet RA. Genetic risk for schizophrenia and psychosis in Alzheimer disease. Mol Psychiatry. 2017 May 2. doi: 10.1038/mp.2017.81
PMID: 28461698.

Sibille E. Reduced Somatostatin Expression or Somatostatin-Positive Gamma-Aminobutyric Acid Neurons: A Shared Pathology Across Brain Disorders. 2017 March 15;81(6):467-469. doi: 10.1016/j.biopsych.2016.12.002. Biological Psychiatry.
PMID: 28190426.

Ferri F, Nikolova YS, Perrucci MG, Costantini M, Ferretti A, Gatta V, Huang Z, Edden R, Moon Q, Sibille E, Stuppia L, Romani GL, Northoff G. A neural “tuning curve” for multisensory experience and cognitive-perceptual schizotypy. 2017 Feb 7. doi: 10.1093/schbul/sbw174.
PMID: 28168302.

Marshe VS, Maciukiewicz M, Rej S, Tiwari AK, Sibille E, Blumberger DM, Karp JF, Lenze EJ, Reynolds CF 3rd, Kennedy JL, Mulsant BH, Müller DJ. Norepinephrine Transporter Gene Variants and Remission From Depression With Venlafaxine Treatment in Older Adults.
2017 Jan 10:appiajp201616050617. doi: 10.1176/appi.ajp.2016.16050617
PMID: 28068779.

Diniz BS, Reynolds CF 3rd, Sibille E, Lin CW, Tseng G, Lotrich F, Aizenstein HJ, Butters MA.
Enhanced Molecular Aging in Late-Life Depression: the Senescent-Associated Secretory Phenotype. 2017 Jan 25. doi: 10.1016/j.jagp.2016.08.018
PMID: 27856124.

2016

Piantadosi SC, French BJ, Poe MM, Timić T, Marković BD, Pabba M, Seney ML, Oh H, Orser BA, Savić MM, Cook JM, Sibille E. Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator. 2016 Nov 22.
PMID: 27920723.

Douillard-Guilloux G, Lewis D, Seney ML, Sibille E. Decrease in somatostatin-positive cell density in the amygdala of females with major depression. Depress Anxiety.
2016 Aug 24. doi: 10.1002/da.22549. [Epub ahead of print]
PMID: 27557481.

Grubisha MJ, Lin CW, Tseng GC, Penzes P, Sibille E, Sweet RA. Age-dependent increase in Kalirin-9 and Kalirin-12 transcripts in human orbitofrontal cortex. Eur J Neurosci. 2016 Jul 29. doi: 10.1111/ejn.13351. [Epub ahead of print]
PMID: 27471199.

Diniz BS, Lin CW, Sibille E, Tseng G, Lotrich F, Aizenstein HJ, Reynolds CF, Butters MA.
Circulating biosignatures of late-life depression (LLD): Towards a comprehensive, data-driven
approach to understanding LLD pathophysiology. J Psychiatr Res.
2016 Jul 11;82:1-7.doi: 10.1016/j.jpsychires.2016.07.006.[Epub ahead of print]
PMID: 27447786.

Belzeaux R, Lin CW, Ding Y, Bergon A, Ibrahim EC, Turecki G, Tseng G, Sibille E.
Predisposition to treatment response in major depressive episode: A peripheral blood gene coexpression network analysis. J J Psychiatr Res.
2016 Jul 9;81:119-126.doi: 10.1016/j.jpsychires.2016.07.009. [Epub ahead of print]
PMID: 27438688.

Oh H, Lewis DA, Sibille E. The Role of BDNF in Age-Dependent Changes of Excitatory and Inhibitory Synaptic Markers in Human Prefrontal Cortex. Neuropsychopharmacology.
2016 Jul 15. doi: 10.1038/npp.2016.126. [Epub ahead of print]
PMID: 27417517.

Diniz BS, Lin CW, Sibille E, Tseng G, Lotrich F, Aizenstein HJ, Reynolds CF, Butters MA.
Circulating biosignatures of late-life depression (LLD): Towards a comprehensive, data-driven approach to understanding LLD pathophysiology. J Psychiatr Res.
2016 Jul 11;82:1-7. doi: 10.1016/j.jpsychires.2016.07.006. [Epub ahead of print]
PMID: 27447786.

Belzeaux R, Lin CW, Ding Y, Bergon A, Ibrahim EC, Turecki G, Tseng G, Sibille E.
Predisposition to treatment response in major depressive episode: A peripheral blood gene coexpression network analysis. J Psychiatr Res.
2016 Jul 9;81:119-126. doi: 10.1016/j.jpsychires.2016.07.009. [Epub ahead of print]
PMID: 27438688.

Zurek AA, Kemp SW, Aga Z, Walker S, Milenkovic M, Ramsey AJ, Sibille E, Scherer SW, Orser BA.
α5GABAA receptor deficiency causes autism-like behaviors. Ann Clin Transl Neurol.
2016 Apr 19;3(5):392-8. doi: 10.1002/acn3.303. eCollection 2016 May.
PMID: 27231709. PMCID: PMC4863752.

Chen CY, Logan RW, Ma T, Lewis DA, Tseng GC, Sibille E, McClung CA.
Effects of aging on circadian patterns of gene expression in the human prefrontal cortex.
Proc Natl Acad Sci U S A.
2016 Jan 5;113(1):206-11. doi: 10.1073/pnas.1508249112. Epub 2015 Dec 22.
PMID: 26699485. PMCID: PMC4711850

2015

Nikolova YS, Iruku SP, Lin CW, Conley ED, Puralewski R, French B, Hariri AR, Sibille E.
FRAS1-related extracellular matrix 3 (FREM3) single-nucleotide polymorphism effects on gene expression, amygdala reactivity and perceptual processing speed: An accelerated aging pathway of depression risk.
Front Psychol.
2015 Sep 16;6:1377. doi: 10.3389/fpsyg.2015.01377. eCollection 2015.
PMID: 26441752. PMCID: PMC4584966.

Ding Y, Chang LC, Wang X, Guilloux JP, Parrish J, Oh H, French B, Lewis D, Tseng GC, Sibille E.
Molecular and Genetic Characterization of Depression: Overlap with other Psychiatric Disorders and Aging. Mol NeuroPsychiatry. 2015 May;1(1):1-12.
PMID: 26213687. PMCID: PMC4512183

McKinney BC, Lin CW, Oh H, Tseng G, Lewis D, Sibille E. Hypermethylation of BDNF and SST Genes in the Orbital Frontal Cortex of Older Individuals: A Putative Mechanism for Declining Gene Expression with Age. Neuropsychopharmacology. 2015 Apr 16. doi:10.1038/npp.2015.107.
PMID: 25881116. PMCID: PMC4569950

Bassi S, Seney ML, Argibay P, Sibille E. Elevated Hippocampal Cholinergic Neurostimulating Peptide precursor protein (HCNP-pp) mRNA in the amygdala in major depression.
J Psychiatr Res. 2015 Apr;63:105-16. doi: 10.1016.
PMID: 25819500. PMCID: PMC4387107

Lin CW, Chang LC, Tseng GC, Kirkwood CM, Sibille EL, Sweet RA.
VSNL1 Co-Expression Networks in Aging Include Calcium Signaling, Synaptic Plasticity, and Alzheimer’s Disease Pathways. Front Psychiatry.2015 Mar 9;6:30. doi: 10.3389.
PMID: 25806004. PMCID: PMC4353182

Lin LC, Sibille E.
Transcriptome changes induced by chronic psychosocial/environmental or neuroendocrine stressors reveal a selective cellular vulnerability of cortical somatostatin (SST) neurons, compared with pyramidal (PYR) neurons. Mol Psychiatry. 2015 Mar;20(3):285. doi: 10.1038/mp.2015.24.
PMID: 25754192. PMCID: PMC4494784

Lin LC, Sibille E.
Somatostatin, neuronal vulnerability and behavioral emotionality.
Mol Psychiatry. 2015 Mar;20(3):377-87. doi: 10.1038/mp.2014.184. Epub 2015 Jan 20.
PMID: 25600109. PMCID: PMC4355106.

Guilloux JP, Bassi S, Ding Y, Walsh C, Turecki G, Tseng G, Cyranowski JM, Sibille E.
Testing the predictive value of peripheral gene expression for nonremission following citalopram treatment for major depression.
Neuropsychopharmacology. 2015 Feb;40(3):701-10. doi: 10.1038/npp.2014.226. Epub 2014 Sep 1.
PMID: 25176167. PMCID: PMC4289958.

Pabba M, Sibille E.: GABA, Depression and Suicide (chapter) in Biological basis of suicidal behavior (ed) of Advances in Biological Psychiatry, Karger Publishing 2015.

2014

Tang S, Ding Y, Sibille E, Mogil J, Lariviere WR, Tseng GC.
Imputation of Truncated p-Values For Meta-Analysis Methods and Its Genomic Application.
Ann Appl Stat.
2014 Dec;8(4):2150-2174.
PMID: 25541588. PMCID: PMC4274812.

Seney ML, Tripp A, McCune S, Lewis D, Sibille E.
Laminar and cellular analyses of reduced somatostatin gene expression in the subgenual anterior cingulate cortex in major depression.
Neurobiol Dis.
2014 Oct 12;73C:213-219. doi: 10.1016/j.nbd.2014.10.005. [Epub ahead of print]
PMID: 25315685. PMCID: Not Available.

Nikolova YS, Koenen KC, Galea S, Wang CM, Seney ML, Sibille E, Williamson DE, Hariri AR.
Beyond genotype: serotonin transporter epigenetic modification predicts human brain function.
Nature Neuroscience.
2014 Sep;17(9):1153-5.
doi: 10.1038/nn.3778. Epub 2014 Aug 3. PMID: 25086606. PMCID: PMC4146649.

Diniz BS, Sibille E, Ding Y, Tseng G, Aizenstein H, Lotrich F, Becker JT, Lopez OL, Lotze MT, Klunk WE, Reynolds CF, Butters MA.
Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression.
Mol Psychiatry.
2014 Aug 5. doi: 10.1038/mp.2014.76.
PMID: 25092249. PMCID: PMC4494754.

Northoff G, Sibille E.
Why Are Cortical GABA Neurons Relevant to Internal Focus in Depression? A cross-level model linking cellular, biochemical, and neural network findings.
Mol psychiatry.
2014 Sep;19(9):966-77. doi: 10.1038/mp.2014.68. Epub 2014 Jul 22.PMID: 25048001. PMCID: PMC4169738. NIHMSID: 597312.

Northoff G, Sibille E.
Cortical GABA neurons and self-focus in depression: a model linking cellular, biochemical and neural network findings.
Molecular psychiatry. 2014.
PMID: 25237734.

Soumier A#, Sibille E.
Opposing Effects of Acute Versus Chronic Blockade of Frontal Cortex Somatostatin-Positive Inhibitory Neurons on Behavioral Emotionality in Mice.
Neuropsychopharmacology.
2014 Apr 1. doi: 10.1038/npp.2014.76.
PMID: 24690741. PMCID: PMC4104344.

Di Narzo AF, Kozlenkov A, Roussos P, Hao K, Hurd Y, Lewis DA, Sibille E, Siever LJ, Koonin E, Dracheva S.
A unique gene expression signature associated with serotonin 2C receptor RNA editing in the prefrontal cortex and altered in suicide.
Hum Mol Genet.
2014 Apr 29. pii: ddu195. [Epub ahead of print].
PMID: 24781207. PMCID: PMC4140462.

Chang LC#, Jamain S, Lin CW, Rujescu D, Tseng GC, Sibille E*.
A Conserved BDNF, Glutamate- and GABA-Enriched Gene Module Related to Human Depression Identified by Coexpression Meta-Analysis and DNA Variant Genome-Wide Association Studies.
PLoS One.
2014 Mar 7;9(3):e90980.
PMID: 24608543. PMCID: PMC3946570.

Diniz BS, Reynolds CF 3rd, Begley A, Dew MA, Anderson SJ, Lotrich F, Erickson KI, Lopez O, Aizenstein H, Sibille EL, Butters MA.
Brain-derived neurotrophic factor levels in late-life depression and comorbid mild cognitive impairment: A longitudinal study.
J Psychiatr Res.
2014 Feb;49:96-101. Epub 2013 Nov 20.
PMID: 24290367. PMCID: PMC3921964.

Senney ML#, Sibille E. Sex differences in mood disorders: perspectives from humans and rodent models. Biol Sex Differ. 2014 Dec 7;5(1):17. doi: 10.1186/s13293-014-0017-3. eCollection 2014.
PMID: 25520774. PMCID: PMC4268901.

French B#, Seney ML, Sibille E. Altered GABA Function in Major Depression. In M Popoli, D Diamond, G Sanacora (eds) Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders, 2014 Springer.

2013

Chang LC#, Lin HM, Sibille E, Tseng GC.
Meta-analysis methods for combining multiple expression profiles: comparisons, statistical characterization and an application guideline.
BMC Bioinformatics.
2013 Dec 21;14(1):368. doi: 10.1186/1471-2105-14-368.
PMID: 24359104. PMCID: PMC3898528.

Seney ML#, Ekong K, Ding Y, Tseng GC, Sibille E*.
Sex chromosome complement regulates expression of mood-related genes.
Biol Sex Differ.
2013 Nov 7, 4:20.
PMID: 24199867. PMCID: PMC4175487.

Lin, Li-Chun#, Sibille E*. Reduced Brain somatostatin in mood disorders: a common pathophysiological substrate and drug target? Front Pharmacol. 2013 Sep 9;4:110.
PMID: 24058344. PMCID: PMC3766825.

Seney ML#, Chang L, Oh H, Wang X, Tseng GC, Lewis DA, Sibille E*.
The role of genetic sex in affect regulation and expression of GABA-related genes across species.
Front Psychiatry.
2013 4:104.
PMID: 24062698. PMCID: PMC3775314

Sibille E*. Will neurobiology rise to the translational challenges and opportunities of late-life geriatric psychiatry? Am J Geriatr Psychiatry. 2013 May;21(5):411-4.
PMID: 23570884.

McKinney BC#, Sibille E*. The Age-by-Disease Interaction Hypothesis of Late-Life Depression. Am J of Geriatric Psychiatry. 2013 May;21(5):418-32. Epub 2013 Feb 6.
PMID: 23075538. PMCID: PMC3549303.

Sibille E*, French B. Biological Substrates Underpinning Diagnosis of Major Depression. Int J Neuropsychopharmacol. 2013 Sep;16(8):1893-909. Epub 2013 May 14.
PMID: 23672886. PMCID: PMC4074859.

Sibille E*. Molecular Aging of the Brain, Neuroplasticity, and Vulnerability to Depression and other Brain-related Disorders. Dialogues Clin Neurosci. 2013 Mar;15(1):53-65.
PMID: 23576889. PMCID: PMC3622469.

Douillard-Guilloux G#, Guilloux JP, Lewis DA, Sibille E*.
Anticipated Brain Molecular Aging in Major Depression.
Am J Geriatric Psychiatry.
2013 May;21(5). Epub 2013 Feb 6.
PMID: 235708880. PMCID: PMC3615087.

Gaiteri C#, Ding Y#, French B, Tseng GC, Sibille E. Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders. Genes Brain Behav. 2014 Jan;13(1):13-24. Epub 2013 Dec 10.
PMID: 24320616. PMCID: PMC3896950.

Pabba M, Sibille E. Sigma-1 and NMDA Receptors: a partnership with beneficial outcomes. Mol NeuroPsychiatry. 1:47-51. doi:10.1159/000376549.

2012

D’Aiuto L, Di Maio R, Heath B, Raimondi G, Milosevic J, Watson AM, Bamne M, Parks WT, Yang L, Lin B, Miki T, Mich-Basso JD, Arav-Boger R, Sibille E, Yolken R, Nimgaonkar V.
Human induced pluripotent stem cell-derived models to investigate human cytomegalovirus infection in neural cells.
PLoS One.
2012; 7(11):e49700 Epub 2012 Nov 27.
PMID: 23209593. PMCID: PMC3507916.

McKinney BC#, Oh Hyunjung, Sibille E*. Age-by-Disease Biological Interactions: Implications for Late-Life Depression. Front Genet. 2012; 3:237. Epub 2012 Nov 16.
PMID: 23162569. PMCID: PMC3499806.

Tripp A#, Oh H#, Guilloux JP, Martinowich K, Lewis DA, Sibille E*.
BDNF Signaling and Subgenual Anterior Cingulate Cortex Dysfunction.
Am J Psychiatry.
2012 Nov 1;169(11):1194-202.
PMID: 23128924. PMCID: PMC3638149.

Wang X#, Kang DD, Shen K, Song C, Lu S, Chang LC, Liao SG, Huo Z, Tang S, Kaminski N, Sibille E, Lin Y, Li J, Tseng GC.
An R package Suite for Microarray Meta-analysis in Quality Control, Differentially Expressed Gene Analysis and Pathway Enrichment Detection.
Bioinformatics.
2012 Aug 3.
PMID: 22863766. PMCID: PMC3463115.

Gaisler-Salomon I, Wang Y, Chuhma N, Zhang H, Golumbic YN, Mihali A, Arancio O, Sibille E, Rayport S.
Synaptic underpinnings of altered hippocampal function in glutaminase-deficient mice during maturation.
Hippocampus.
2012 May;22(5):1027-39. Epub 2012 Mar 19.
PMID: 22431402. PMCID: PMC3531559.

Edgar N#, Sibille E*. A Putative Functional Role for Oligodendrocytes in mood regulation. Transl. Psychiatry. 2012 May 1;2:e109. doi: 10.1038/tp.2012.34.
PMID: 22832953. PMCID: PMC3365253.

Wang X#, Lin Y, Song C, Sibille E, Tseng G.
Detecting disease-associated genes with confounding variable adjustment and the impact on genomic meta-analysis: with application to major depressive disorder.
BMC Bioinformatics.
2012 Mar 29;13(1):52.
PMID: 22458711. PMCID: PMC3342232.

Seney M#, Walsh C, Sibille E*.
Neonatal testosterone partially organizes sex differences in high emotionality induced by chronic stress in mice.
Neurobiology of Disease.
2012. May; 46(2): 486-96. Epub 2012 Feb 28.
PMID: 22394611. PMCID: PMC3323718.

Joeyen-Waldorf J#, Nikolova Y, Edgar N, Walsh C, Kota R, Lewis DA, Ferrell R, Manuck S, Hariri A, Sibille E*.
Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry.
Biol Psychiatry.
2012 Jan. 19.
PMID: 22264442
PMCID: PMC3307939.

Guilloux JP#, Douillard-Guilloux G, Kota R, Wang X, Gardier A, Martinowich K, Tseng G, Lewis DA, Sibille E*: Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression.
Mol Psychiatry.
2012 Nov; 17(11):1130-42. Epub 2011 Sep 13.
PMID: 21912391. PMCID: PMC3237836.

Sibille E*. Genomics of Depression. McGraw-Hill Yearbook of Science & Technology. 2012

2011

Kupfer D, Angst J, Berk M, Dickerson F, Frangou S, Frank E, Goldstein B, Harvey A, Laghrissi-Thode F, LeBoyer M, Ostacher M, Sibille E, Strakowsi S, Suppes T, Tohen M, Yolken R, Young L, Zarate C. Advances in bipolar disorder: selected sessions from the 2011 International Conference on Bipolar Disorder. Ann N YAcad Sci. 2011 Dec;1242(1):1-25.
PMID: 22191553.

Almeida JR, Kronhaus DM, Sibille E, Langenecker S, Versace A, Labarbara EJ, Phillips ML.
Abnormal left-sided orbitomedial prefrontal cortical-amygdala connectivity during happy and fear face processing: a potential neural mechanism of female MDD.
Front Psychiatry.
2011;2:69. Epub 2011 Dec 8.
PMID: 22163223. PMCID: PMC3233901.

Glorioso C#, Sibille E*. Between Destiny and Disease: Genetics and Molecular Pathways of Human Central Nervous System Aging. Progress in Neurobiology. 2011 Feb;93(2):165-81 Epub 2010 Dec 2.
PMID: 21130140. PMCID: PMC3034779.

Kang D, Sibille E, Kaminski N, and Tseng G.
MetaQC: Objective Quality Control and Inclusion/Exclusion Criteria for Genomic Meta-Analysis.
Nucleic Acids Research.
2011 Nov 23.
PMID: 22116060. PMCID: PMC3258120.

Edgar NM#, Touma C, Palme R, Sibille E*:
Resilient emotionality and molecular compensation in mice lacking the oligodendrocyte-specific gene Cnp1.
Translational Psychiatry.
2011 Sep 20; 1(9): e42.
PMID: 22832658. PMCID: PMC3309485.

Lin L#, Lewis DA, Sibille E*:
A human-mouse conserved sex bias in amygdala gene expression affecting circadian clock and energy metabolism.
Molecular Brain.
2011 May 4;4(1):18.
PMID: 21542937. PMCID: PMC3098780.

Tripp A#, Kota R, Lewis DA, Sibille E*.
Reduced Somatostatin in Subgenual Anterior Cingulate Cortex in Major Depression.
Neurobiology of Disease.
2011 Apr;42(1):116-24 Epub 2011 Jan 11.
PMID: 21232602. PMCID:PMC3039077. NIHMSID:264767.

Gaiteri C#, Sibille E*:
Differentially expressed genes in depression reside on the periphery of resilient gene coexpression networks.
Front. Neurosci.
2011 5:95. Epub 2011 Aug 30.
PMID: 21922000. PMCID: PMC3166821.

Sibille E*, Morris H, Kota R, Lewis DA.
GABA-related transcripts in the Dorsolateral Prefrontal Cortex in Mood Disorders.
Int J Neuropsychopharmacol.
2011 Jan 13:1-14 [Epub ahead of print]
PMID: 21116980.

Guilloux J-P#, Seney M, Edgar N, Sibille E*.
Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: Relevance to emotionality and sex.
J Neurosci Methods.
2011 Apr15;197(1):21-31.Epub 2011 Jan 26.
PMID: 21277897. PMCID: PMC3086134.

Glorioso C#, Oh S, Douillard GG, Sibille E*.
Brain Molecular Aging, Promotion of Neurological Disease and Modulation by Sirtuin5 Longevity Gene Polymorphism.
Neurobiology of Disease.
2011 Feb;41(2):279-90, Epub 2010.
PMID: 20887790. PMCID: PMC3014380.

Altieri S, Singh Y, Sibille E, Andrews A: Serotonergic Pathways in Depression. In F Lopez-Munoz, C Alamo (eds) Neurobiology of Depression, CRC Press, 143-59. 2011.

2010

Gaiteri C#, Guilloux JP, Lewis DA, Sibille E*.
Altered Gene Synchrony Suggests a Combined Hormone-Mediated Dysregulated State in Major Depression.
PloS One.
2010 Apr 1;5(4):e9970.
PMID: 20376317. PMCID: PMC2848620.

Guilloux JP#, Gaiteri C, Sibille E*.
Network analysis of positional candidate genes of schizophrenia highlights more than myelin-related pathways.
Mol Psychiatry.
Epub 2010 March 30.
PMID: 20351722. PMCID: PMC2921453. NIHMSID: 206185.

Tripp A#, Sibille E*. Rodent behavioral models in serotonin transporter knockout: emotional dysregulation. In AV Kalueff (ed) Experimental models in serotonin transporter research, Cambridge University Press, 2010.

Edgar N#, Sibille E*. Genetically modified animals. In I Stolerman (ed) Encyclopedia of Psychopharmacology, Springer-Verlag Publishers, 2010.

2009

Oh S#, Tseng GC, Sibille E*.
Reciprocal Phylogenetic Conservation of Molecular Aging in Mouse and Human Brain.
Neurobiology of Aging.
2009 Sep 1. [Epub ahead of print]
PMID: 19729224. PMCID: PMC2888783. NIHMSID: 138294

Sibille E*, Wang Y, Joeyen-Waldorf J, Gaiteri C, Surget A, Oh S, Belzung C, Tseng GC, Lewis DA., M.D.
A Molecular Signature of Depression in the Amygdala.
Am J Psychiatry.
2009 Sep;166(9):1011-24. Epub 2009 Jul 15.
PMID: 19605536. PMCID: PMC2882057. NIHMSID: 206316.

Surget A#, Wang Y, Leman S, Ibarguen-Vargas Y, Edgar N, Griebel G, Belzung C, Sibille E*.
Corticolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal.
Neuropsychopharmacology.
2009 May;34(6):1363-80. Epub 2008 Jun 4.
PMID: 18536703. PMCID: PMC2669699.

Joeyen-Waldorf J#, Edgar N, Sibille E*.
The roles of sex and serotonin transporter levels in age- and stress-related emotionality in mice.
Brain Res.
2009 Aug 25;1286:84-93. Epub 2009 Jul 3.
PMID: 19577546. PMCID: PMC2723171.

Romcy-Pereira RN#, Erraji-Benchekroun L, Smyrniotopoulos P, Ogawa S, Mello CV, Sibille E, Pavlides C.
Sleep-dependent gene expression in the hippocampus and prefrontal cortex following long-term potentiation.
Physiol Behav.
2009 Aug 4;98(1-2):44-52. Epub 2009 Apr 20.
PMID: 19389414. PMCID: PMC2707503.

2008

Sibille E*, Joeyen-Waldorf J, Wang Y, Arango V, Mann J, Leman S, Surget A, Belzung C, Lewis, DA.
Large-scale estimates of cellular origins of mRNAs: Enhancing the yield of transcriptome analysis.
J Neurosci Methods.
2008 Jan 30;167(2):198-206. Epub 2007 Aug 21.
PMID: 17889939. PMCID: PMC2262176.

Beneyto M, Sibille E, Lewis DA. Human postmortem brain research in mental illness syndromes. In DS Charney, EJ Nestler (eds) Neurobiology of Mental Illness, 3e, Oxford University Press, 2008.

2007

Sibille E*, Su J, Leman S, Le Guisquet AM, Ibarguen-Vargas Y, Joeyen-Waldorf J, Glorioso CA, Tseng G, Pezzone M, Hen R, Belzung C.
Upregulated sirtuin 5 gene expression in frontal cortex of serotonin 1b receptor knock out mice.
Mol Psychiatry.
2007;12(11):975.
doi:10.1038/sj.mp.4002115.

Sibille E*, Su J, Leman S, Le Guisquet AM, Ibarguen-Vargas Y, Joeyen-Waldorf J, Glorioso CA, Tseng G, Pezzone M, Hen R, Belzung C.
Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity.
Mol Psychiatry.
2007. Nov;12(11):1042-56, 975. Epub 2007 Apr 10.
PMID: 17420766. PMCID: PMC2515886.

Sibille E, Lewis D. SERT-ainly involved in depression, but when? Am J Psychiatry. 2006 Jan;163(1):8-11.
PMID: 16390880.

2006

Weisstaub NV, Zhou M, Lira A, Lambe E, Gonzalez-Maeso J, Hornung JP, Sibille E, Underwood M, Itohara S, Dauer WT, Ansorge MS, Morelli E, Mann JJ, Toth M, Aghajanian G, Sealfon SC, Hen R, Gingrich JA.
Cortical 5-HT2A receptor signaling modulates anxiety-like behavior in mice.
Science.
2006 Jul 28;313(5786):536-40.
PMID: 16873667.

Bach-Mizrachi H, Underwood MD, Kassir SA, Bakalian MJ, Sibille E, Tamir H, Mann JJ, Arango V.
Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide.
Neuropsychopharmacology.
2006 Apr;31(4):814-24.
PMID: 16192985.

Leonardo ED, Richardson-Jones JW, Sibille E, Hen R.
Molecular heterogeneity along the dorsal-ventral axis of the murine hippocampal CA1 field: a microarray analysis of gene expression.
Neuroscience.
2006;137(1):177-86. Epub 2005 Nov 23.
PMID: 16309847.

2005

Barr GA, Gao P, Wang S, Cheng J, Qin J, Sibille E, Pavlidis P.
Microarray analysis of gene expression following the fomalin test in the infant rat.
Pain.
2005 Sep;117(1-2):6-18.
PMID: 16043289.

Erraji-Benchekroun L#, Underwood MD, Arango V, Galfalvy H, Pavlidis P, Smyrniotopoulos P, Mann JJ, Sibille E*.
Molecular aging in human prefrontal cortex is selective and continuous throughout adult life.
Biol Psychiatry.
2005 Mar 1;57(5):549-58.
PMID: 15737671.

2004

Pavlidis P, Qin J, Arango V, Mann JJ, Sibille E.
Using the gene ontology for microarray data mining: a comparison of methods and application to age effects in human prefrontal cortex.
Neurochem Res.
2004 Jun;29(6):1213-22.
PMID: 15176478.

Sibille E*, Arango V, Galfalvy H, Pavlidis P, Ellis S, Mann JJ.
Gene expression profiling of depression and suicide in human prefrontal cortex.
Neuropsychopharmacology.
2004 Feb;29(2):351-61.
PMID: 14603265.

2003

Galfalvy H#, Erraji-Benchekroun L, Smyrniotopoulos P, Pavlidis P, Ellis S, Mann JJ, Sibille E*, Arango V.
Sex genes for genomic analysis in human brain: internal controls for comparison of probe level data extraction.
BMC Bioinformatics.
2003 Sep 8;4:37. Epub 2003 Sep 8.
PMID: 12962547. PMCID: PMC212256

Liu W, Seto J, Sibille E, Toth M.
RNA binding domain of Jerky consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs.
Mol Cell Bio.
2003 Jun;23(12):4083-93.
PMID: 12773553. PMCID: PMC156124

2002

Galfavy H#, Ellis S, Mann JJ, Sibille E*.
Standardizing gene expression data from high-density oligonucleotide microarrays in a matched pair study.
Proc Am Stat Assoc.
2002;12:95-99.

Sibille E, Hen R.
Combining genetic and genomic approaches to study mood disorder.
Eur Neuropsychopharmacol.
2001 Dec;11(6):413-21.
PMID: 11704418.

2001

Sibille E, Hen R. Serotonin1A receptors in mood disorders. A combined genetic and genomic approach. Behav Pharmacol. 2001 Nov;12(6-7):429-38.
PMID: 11742136.

He M#, Sibille E#, Benjamin D, Toth M, Shippenberg T.
Differential effects of 5-HT(1A) receptor deletion upon basal and fluoxetine-evoked 5-HT concentrations as revealed by in vivo microdialysis.
Brain Res.
2001 May 25;902(1):11-7.
PMID: 11376590.

Santarelli L, Debs P, Gobbi G, Sibille E, Yamamoto A, Blier P, Hen R, Heath M.
Genetic and pharmacological disruption on neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function.
Proc Natl Acad Sci U S A.
2001; 98:1912-1917.
PMID: 11172050. PMCID: PMC29356.

2000

Sarnyai Z, Sibille E, Pavlides C, Fenster R, McEwen BS, Toth M.
Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking 5-HT1A receptors.
Proc Natl Acad Sci U S A.
2000;97:14731-6.
PMID: 11121072. PMCID: PMC18987.

Sibille E, Pavlides C, Benke D, Toth M.
Genetic inactivation of the Serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety.
J Neurosci.
2000 Apr 15;20(8):2758-65.
PMID: 10751426.

Sarnyai Z, Sibille E, Pavlides C, Fenster RJ, McEwen BS, Toth M. Functional abnormalities in the hippocampus and impaired hippocampal-4dependent learning in mice lacking the 5HT(1A) receptors. CNS Drug Rev 6: 40-40 Suppl. 1, 2000.

1999

Chen L, He M, Sibille E, Thompson A, Sarnyai Z, Baker H, Shippenberg T, Toth M.
Adaptive changes in postsynaptic dopamine receptors despite unaltered dopamine dynamics in mice lacking monoamine oxidase B.
J Neurochem.
1999 Aug;73(2):647-55.
PMID: 10428061.

1998

Parks C, Robinson T, Sibille E, Shenk T, Toth M.
Increased anxiety of mice lacking the serotonin1A receptor.
Proc Natl Acad Sci U S A.
1998;95:10734-10739.
PMID: 9724773. PMCID: PMC27964.